Isolation of a novel antifungal peptide from the bark of Eucommia ulmoides Oliv |
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| Authors: | Liu Shihui Zhao Degang Han Yuzhen |
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| Institution: | 1. Guizhou Key Laboratory of Agricultural Bioengineering, College of Life Sciences, Guizhou University, Guiyang 550025, P.R.China;Key Laboratory of Green Pesticide and Agricultural Biological Engineering, Ministry of Education, Guizhou University, Guiyang 550025, P.R.China
2. College of Biological Sciences, China Agricultural University, Beijing 100094, P.R.China |
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| Abstract: | A novel Eucommia antifungal peptide, named EAFP3, was isolated from the bark of Eucommia ulmoides by NaCl extract, gel filtration and reverse phase high performance liquid chromatography. The molecular mass of EAFP3 is 4157.3 Da, and its partial amino acid sequence is -.LYQQLIAGITLNK.-. EAFP3 exerts an inhibitory activity against Candida albicans in vitro and the drug concentration required for 50% growth inhibition (IC50) is 31.25μg/mL. |
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| Keywords: | antifungal peptide isolation the bark of Eucommia ulmoides Oliv Candida albicans |
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