丹参川芎嗪治疗早期糖尿病肾病临床效果及对炎性因子影响

目的 探讨丹参川穹嗪对早期糖尿病肾病的临床治疗效果及对患者体内炎性因子的影响.方法 选取87例早期糖尿病肾病患者为研究对象,将其按照不同治疗方法分为对照组和研究组,对照组44例,采用常规方法治疗;研究组43例,在对照组基础上添加丹参川穹嗪进行治疗,观察两组患者治疗的总有效率及不良反应发生率,并将两组患者的UAER,UACR,β2-MG及血清IL-6,IL-18,TNF-α进行观察和比较.结果 对照组患者总有效率及不良反应发生率分别为78.57%和23.81%;治疗后UAER,UACR,β2-MG分别为(110.31±19.27)mg/d,(81.46±9.46)mg/g,(17.69±4.68)mg/L;血清IL-6,IL-18,TNF-α分别为(12.13±2.10),(135.21±37.23),(39.21±11.25)mg/L.研究组患者总有效率及不良反应发生率分别为95.12%,4.88%;治疗后UAER,UACR,β2-MG分别为(92.16±21.39)mg/d,(67.14±8.15)mg/g,(13.62±4.21)mg/L;血清IL-6,IL-18,TNF-α分别为(8.05±2.01),(103.26±32.85),(23.68±11.84)mg/L.两组间各数据比较差异具有统计学意义(P<0.05).结论 丹参川穹嗪在早期糖尿病肾病的治疗中能够有效降低患者体内炎性因子水平.

Clinical Effect of Danshen Chuanxiongqin Injection on the Early Diabetic Nephropathy and Its Effects on Inflammatory Factors

Objective To investigate the clinical effect of Danshen Chuanxiongqin injection on the early diabetic nephropathy and its effects on inflammatory factors in the body of patients.Method Eighty-seven patients with early diabetic nephropathy were enrolled in this study.They were randomly divided into control group and study group.Forty-four patients in the control group were treated with the conventional method and 43 patients in the study group with Danshen Chuanxiongqin injection in combination with the conventional method.The total effective rate and the incidence of adverse reactions were observed,and UAER,UACR and β2-MG,and serum IL-6,IL-18 and TNF-α levels were compared between the two groups.Results The total effective rate and the incidence of adverse reactions in the control group were 78.57% and 23.81%,respectively.After treatment,UAER,UACR and β2-MG were (110.31 ± 19.27) mg/d,(81.46 ± 9.46) mg/g,and (17.69±4.68)mg/L,respectively;serum IL-6,IL-18 and TNF-α were (12.13±2.10) mg/L,(135.21±37.23) mg/L,and (39.21±11.25) mg/L,respectively.The total effective rate and incidence of adverse reactions in the study group were 95.12% and 4.88%,respectively;after treatment,UAER,UACR and β2-MG were (92.16 ± 21.39) mg/d,(67.14 ± 8.15) mg/g,and(13.62±4.21)mg/L,respectively;.serum IL-6,IL-18 and TNF-α levels were (8.05 ± 2.01) mg/L,(103.26 ± 32.85) mg/L,and (23.68 ± 11.84) mg/L,respectively.The differences in the above data between the two groups were statistically significant (P<0.05).Conclusion Danshen Chuanxiongqin can effectively reduce the level of inflammatory factors in patients with the early diabetic nephropathy,which is worthy of popularization and application.