血清CysC,Hcy及PTH水平对慢性肾衰竭患者的临床作用

目的探讨慢性肾衰竭(CRF)患者血清胱抑素C(Cys C)、同型半胱氨酸(Hcy)及甲状腺激素(PTH)水平变化的临床作用及意义.方法筛选CRF患者129例作为CRF组,并选取同时期健康体检者129例为对照组,CRF组患者入院后针对病情给予相应治疗,检测CRF组治疗前后血清肌酐(Scr)、尿素氮(BUN)、Cys C、Hcy及PTH水平变化,分析不同分期CRF患者各指标的水平差异,并与对照组进行对比分析,分析Scr,BUN与Cys C,Hcy及PTH的相关性.结果 CRF组患者治疗前血清中Scr,BUN,Cys C,PTH和Hcy指标与对照组比较明显偏高,差异具有统计学意义(P0.05);CRF组患者接受治疗后上述各指标均明显降低,与治疗前比较差异具有统计学意义(P0.05);接受治疗的CRF组患者血清中各项指标未能达到对照组正常水平.CRF组患者血清各指标随分期发展呈递增趋势,由低到高分别为:肾功能代偿期、肾功能不全期、肾功能衰竭期、尿毒症终末期,各期比较差异均具有统计学意义(P0.05);CRF组患者的Scr,BUN经Pearson相关性分析显示其水平分别与Cys C,Hcy,PTH的水平呈正相关.结论 Hcy,Cys C及PTH水平可以特异性的反映CRF患者肾病严重程度及病程,准确判断患者疾病发展情况,为CRF患者的临床诊断提供参考.

Clinical Significance of Serum Levels of CysC,Hcy and PTH in Patients with Chronic Renal Failure

Objective To investigate the clinical significance of serum cystatin C ( CysC) ,homocysteine ( Hcy) and thyroid hormone ( PTH) levels in patients with chronic renal failure ( CRF) ,and provide a new method for the diagnosis of CRF. Method 129 CRF patients were selected as study group,and 129 healthy people through physical examination during the same period were chosen as control group. The patients in the study group were given the corresponding treatment,and before and after treatment,their serum creating ( Scr) ,blood urea nitrogen (BUN),CysC,Hcy and PTH level changes were detected. Differences in the level of detected indexes in the different stages were analyzed and compared with those in the control group,and the correlation of BUN and Scr with CysC,Hcy and PTH was analyzed. Results Before treatment,serum Scr,BUN,CysC,PTH and Hcy levels of CRF patients were significantly higher than those in the control group,with statistically significant differences (P<0. 05);after treatment,the above indexes of CRF patients were significantly decreased,showing statisticallysignificant difference compared with those before treatment ( P<0. 05 );after treatment, the indexes of CRF patients in the study group did not reach to the normal levels which were shown in the control group. Each index in CRF group with the development of stages showed the same increasing trend,respectively,and the order from low to high level was the compensated stage, decompensated stage, renal failure, and end-stage uremia, with statistically significant differences at the different stages ( P<0. 05 );The patients with by Pearson correlation analysis in CRF group showed that the level of Scr and BUN was positively correlated with that of CysC,Hcy and PTH. Conclusion Hcy,CysC and PTH levels can specifically reflect the severity of CRF,be used for evaluating the development of CRF,which can provide reference for the clinical diagnosis of patients with CRF.