原发性干燥综合征血液系统损伤患者免疫学特性分析

目的 探讨原发性干燥综合征(primary sjogren syndrome,PSS)合并血液系统损伤患者免疫学特点.方法 选择158例PSS患者为研究对象,研究其临床表现、血常规情况、抗核抗体(antinuclearantibody,ANA)、抗SSA抗体、抗SSB抗体以及类风湿因子(rheumatoid factor,RF)检测结果,分析不同血液系统改变患者免疫学指标的特征.结果 158例PSS患者中存在血液系统损伤107例,发生率为67.7%;其中贫血69例(43.7%),血小板减少41例(25.9%),白细胞减少50例(31.6%).血液系统损伤组抗SSA抗体、抗SSB抗体阳性发生率均明显高于无血液系统损伤组,差异具有显著统计学意义(P<0.01).结论 血液系统损伤在PSS患者中较为常见,抗SSA和抗SSB抗体可能与PSS患者血液系统损伤的发生有关.

Analysis of the Immunological Characteristics in Patients with Primary Sjogren Syndrome with Hematological Damages

Objective To explore the immunological characteristics of patients with primary sjogren syndrome (Pss) complicated with hematological damages.Method 158 patients with PSS were enrolled in this study.The clinical features,blood routine examination,antinuclearantibody,anti-SSA antibodies,anti-SSB antibodies and rheumatoid factor (RF) were detected,and the immunological characteristics were analyzed between PSS complicated with and without hematological damages.Results 107 patients had hematological damages among 158 patients with PSS,and the occurrence rate was 67.7% of them,there were 69 patients (43.7%) with anemia,41 patients (25.9%) with thrombocytopenia,and 50 patients (31.6%) with leucopenia.The positive rates of anti-SSA antibodies and anti-SSB antibodies in the hematological damages group were higher than those in the non-hematological damages group (P<0.05).Conclusion The hematological damages are common in patients with PSS.Anti-SSA antibodies and anti-SSB antibodies may be closely associated with the hematological damages.