幽门螺旋杆菌感染与血型抗原相关性研究

目的通过观察幽门螺杆菌(Helicobacter pylori,Hp)在各血型患者中的分布情况,分析Hp感染与ABO血型、Lewis血型、分泌-非分泌表型的关系.方法收集幽门螺旋杆菌感染患者100例为感染组,100例健康的无偿献血者为对照组,分析两组患者的ABO血型系统、血型物质、Lewis血型系统的分布差异.结果 ABO血型分布比较:感染组O型血占56%(56/100),高于对照组的31%(31/100),感染组A型血占16%(16/100),低于对照组的33%(33/100).卡方检验结果显示:感染人群中O型血有较高发生率(56%),和普通人群中A型血(33%)之间具有显著性统计学意义(P0.05).ABO血型与幽门螺杆菌感染之间有相关性,O型人有较高感染倾向,而A型血则有较低感染倾向.Lewis表型分布比较:分析整个数据,感染组与对照组的表型分布基本一致,说明Lewis表型分布不受幽门螺杆菌感染的影响,感染组各表型与对照组比较差异无统计学意义.血型物质分布比较:分泌型个体分布在感染组和对照组之间比较差异无统计学意义.结论幽门螺杆菌感染与O型血有较强的关联,但与Lewis血型、分泌-非分泌表型无关.

Research on the Relationship between the Helicobacter pylori Infection and Blood Group Antigens

ObjectiveTo analyze the relationship between H.pylori infection and ABO blood group,Lewis phenotype,secretor and non-secretor phenotype by observing the patients with different blood groups infected with H.pylori.MethodOne hundred patients infected with H.pylori were selected as the observation group and one hundred unpaid volunteer blood donators were randomly selected as the control group.The differences in ABO blood group,Lewis phenotype,secretor and non-secretor phenotype were analyzed.ResultsDistribution comparison of ABO blood group:there were 56% (56/100) patients with type O infected with H.pylori in the observation group,which were higher than those in the control group 31%(31/100);There were 16% (16/100) patients with type A in the observation group,which were lower than those in the control group 33% (33/100),showing statistically significant differences (P<0.05).There was a correlation between ABO blood group and H.pylori infection,type O people have a higher risk of infection with H.pylori and type A people have a lower risk of infection with H.pylori Lewis phenotype:The date showed that the phenotypic distribution of the bservation group and the control group were basically consistent,indicating that the Lewis phenotypic distribution should not be affected by the infection of H.pylori.Compared with the control group,the distribution of the different phenotypes was not statistically different (P>0.05).Secretor and non-secretor phenotype:There was no statistical significance between the two groups (P>0.05).ConclusionThere is a certain correlation between H.pylori infection and type O,but no correlation with Lewis phenotype,and secretor and non-secretor phenotype.