| 十字花科植物中异硫氰酸盐的性质及活性研究 |
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| 引用本文： | 李雷,邹翔,季宇彬.十字花科植物中异硫氰酸盐的性质及活性研究[J].哈尔滨商业大学学报(自然科学版),2007,23(4):385-389,399. |
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| 作者姓名： | 李雷 邹翔 季宇彬 |
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| 作者单位： | 哈尔滨商业大学,生命科学与环境科学研究中心,哈尔滨,150076;哈尔滨商业大学,药物所博士后科研工作站,哈尔滨,150076 |
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| 基金项目： | 国家自然科学基金项目(30300284,30400592)，黑龙江省自然科学基金重大项目(ZJY03-04)，哈尔滨市科技攻关项目(2004AA9CN164) |
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| 摘 要： | 对十字花科植物中的异硫氰酸盐(ITCs)的结构及性质进行分析,并对其抑制I相酶、诱导II相酶的活性及诱导肿瘤细胞凋亡使细胞周期停止等主要抗癌机制进行探讨.目前,国外已经将SFN产品上市销售,并可以治疗高血压、白内障等棘手性疾病.对异硫氰酸盐的结构性质及药理活性作以综述.
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| 关 键 词： | 十字花科植物 异硫氰酸盐 莱菔硫烷 抗肿瘤 |
| 文章编号： | 1672-0946（2007）04-0385-05 |
| 收稿时间： | 2006-09-03 |
| 修稿时间： | 2006-09-03 |
Study on characteristic and pharmacological bioactivity of isothiocyanates in natural cruciferious vegetables |
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| LI Lei,ZOU Xiang,JI Yu-bin.Study on characteristic and pharmacological bioactivity of isothiocyanates in natural cruciferious vegetables[J].Journal of Harbin University of Commerce :Natural Sciences Edition,2007,23(4):385-389,399. |
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| Authors: | LI Lei ZOU Xiang JI Yu-bin |
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| Institution: | 1. Center of Research and Development on Life Sciences and Environmental Sciences , Harbin University of Commerce , Harbin 150076 , China ;2. Institute of Materia Medica and Postdoctoral Programme of Harbin University of Commerce , Harbin 150076 , China |
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| Abstract: | This paper shows several structures of crude isothiocyanates and its mainly physical and chemical activities.The mechanism of anticancer has been plausible.The passage from two substantial ways to expound it.Sulforaphane was thought to be due solely to its ability to behave as a monofunctional inducer of phase II enzymes,which are known to represent the most important group of detoxication enzymes of the human organism,and it has also been shown to be the inhibitor of phase I enzymes.Besides,it also can induced apoptosis to let the cancer cells death.For the time being,the production of ITCs has been a effective medicine of hypertension and cataract.This paper describes the structures characteristics and pharmacological bioactivity of I-TCS from different aspects. |
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| Keywords: | cruciferious vegetables isothiocyanates sulforaphane anticancer |
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