A possible mode of the specific recognition of nucleic acids by proteins |
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| Authors: | Xuqing Li Ciquan Liu |
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| Institution: | (1) Department of Computer Science, Kunming University of Science and Technology, 650041 Kunming, China;(2) Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223 Kunming, China;(3) Yunnan Observatory, Chinese Academy of Sciences, 650011 Kunming, China;(4) Modern Biological Center, Yunnan University, 650091 Kunming, China |
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| Abstract: | Seven sets of protein target sites, which occur in several gene promoters, have been analyzed. The results suggest that there
is a possible mode of specific recognition of double-helical nucleic acids by proteins. This recognition mode is related to
a special topological property of double-helical DNA, which is termed base spatial pattern (BSP) of DNA segment. BSP is the
spatial topological property determined only by the spatial arrangement of the bases on double-helical DNA segment. |
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| Keywords: | protein nucleic acids recognition base spatial pattern (BSP) target sites |
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