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Substance P-induced fibrinolysis in the forearm of healthy humans
Authors:M Fanciullacci  S Fedi  M Alessandri  U Pietrini
Institution:(1) Institute of Internal Medicine and Therapeutics IV, University of Florence, Viale Pieraccini, 18, I-50139 Florence, (Italy);(2) Institute of Internal Medicine and Therapeutics I, University of Florence, Florence, (Italy)
Abstract:Physiological saline with or without substance P (50 ng/ml) was infused into the humeral artery in 6 healthy males. Indices of fibrinolytic activity (whole blood diluted lysis time, euglobulin lysis time, lysis areas in non-heated fibrin plates produced by plasma or euglobulin precipitate, plasminogen plasma levels, agr2-macroglobulin, Cl-inhibitor, and agr2-antiplasmin) were evaluated in the homolateral antecubital vein before and after 5 min of substance P or saline infusion. After substance P the fibrinolytic activity increased, as can be seen from the shortening of lysis times (p<0.01) and enlargement of the lysis areas (p<0.01). A reduction of plasminogen plasma levels (p<0.01), associated with a decrease in agr2-anitplasmin (p<0.01), was also found. Alpha2-macroglobulin and Cl-inhibitor were instead unaltered by the peptide. The saline infusion, on the other hand, was unable to modify any of the examined indices. We concluded that exogenous substance P given intra-arterially increases fibrinolytic activity in locally-sampled venous blood through a mechanism which remains to be elucidated.
Keywords:Substance P  fibrinolysis  plasminogen  agr2-antiplasmin" target="_blank">gif" alt="agr" align="BASELINE" BORDER="0">2-antiplasmin  healthy humans
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