半参数技术在生物医学领域中的应用

近年来半参数技术越来越多地应用于生物特征的识别，相关研究成果（出版物）逐年增加。到目前为止，该技术已用于生物医学领域的各种研究，对此有必要对其应用情况进行及时总结，这将有助于对其发展趋势及应用有一个全面了解。本文综述了半参数技术在不同生物医学领域的应用，包括接受者操作特征（ROC）分析、生存和纵向分析、药代动力学和药效学、暴露研究、基因研究及其它研究领域。其中每一部分以对半参数技术背景的一般描述开始，进而介绍其适用情况，最后对不同的研究加以比较，使大家对半参数技术的应用背景、适用情况、与参数和非参数方法相比的优点以及在疾病诊断中的协变量有概念性认识。

Application of Semiparametric Technique in Biomedical Fields

Over recent years,semiparametric technique becomes to have more and more applica-tions in biometrics as evidenced in the number of publications per year.Therefore it is necessary and timely to review semiparametric technique’s applications in biomedical researches in order that we can get not only a whole picture on its development tendency but also some insights in-to its applications.In this review,we addressed the application of semiparametric technique in different biomedical fields,including receiver operating characteristic （ROC）analysis,survival and longitudinal analysis,pharmacokinetics and pharmacodynamics,exposure study,genetic study and other research fields.In each section,we started from general views on the back-ground of semiparametric technique,advanced to its applicable circumstances and finished with comparison studies,through which one would have a general view on the background of applica-tions,applicable cases,advantages in comparison with parametric and nonparametric tech-niques,and covariates in diseases,which can be applicable for semiparametric technique.