| 新型脱碳木脂素类化合物合成方法与肿瘤抑制活性研究 |
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| 引用本文： | 向建南,刘开建,李君姊,梁志武.新型脱碳木脂素类化合物合成方法与肿瘤抑制活性研究[J].湖南大学学报(自然科学版),2012,39(9):62-66. |
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| 作者姓名： | 向建南 刘开建 李君姊 梁志武 |
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| 作者单位： | 湖南大学化学化工学院 |
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| 基金项目： | 湖南省自然科学基金资助项目(11JJ5008) |
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| 摘 要： | 利用Mn(Ⅱ)/Co(Ⅱ)/PhP(O)HOR/O2新催化体系合成了一系列新型脱碳木脂素类化合物(2a～2g),并采用MTT比色实验法,研究了所合成化合物体外抗肿瘤抑制活性.分别对人乳腺癌细胞(MCF-7),人肝癌细胞(Bel-7402),人肺癌(A549)和人子宫颈癌细胞(Hela)进行检测.结果表明:化合物2a～2g对4种癌细胞均有较强的抑制作用,尤其是对人肝癌细胞Bel-7402的抑制效果明显,其中化合物2b显示出比相同条件下紫杉醇更好地抗癌抑制活性(IC50:18.9μg/mL),说明所合成的芳基烯二聚化合物2b具有更好的应用前景。
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| 关 键 词： | 脱碳木脂素 催化二聚 肿瘤抑制活性 合成 |
Study on Synthesis and Anticancer Activities of New Norlignans Derivatives |
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| XIANG Jian-nan,LIU Kai-jian,LI Jun-zhi,LIANG Zhi-wu.Study on Synthesis and Anticancer Activities of New Norlignans Derivatives[J].Journal of Hunan University(Naturnal Science),2012,39(9):62-66. |
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| Authors: | XIANG Jian-nan LIU Kai-jian LI Jun-zhi LIANG Zhi-wu |
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| Institution: | (College of Chemistry and Chemical Engineering,Hunan Univ,Changsha,Hunan 410082,China) |
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| Abstract: | In this study,we have synthesized a series of new norlignan compounds 2a-2g and evaluated their anticancer activities with MTT assay by using human hepaioma Bel-7402 cells,human breast adenocarcinoma MCF-7 cells,human lung carcinoma A549 cells and human cervical carcinoma HeLa cells.It has been shown that the products(2a-2g) exhibit higher cytotoxicity to cells,and especially,product 2b treated with Bel-7402 cells shows a lower cytotoxicity(IC50: 18.9 μg/mL) than free paclitaxel. |
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| Keywords: | norlignans catalytic dimerization anticancer activities synthesis |
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