The importance of HLA-G expression in embryos,trophoblast cells,and embryonic stem cells |
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| Authors: | Roberta?Rizzo Martine?Vercammen Hilde?van de?Velde Peter?A?Horn Email author" target="_blank">Vera?RebmannEmail author |
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| Institution: | (1) Department of Experimental and Diagnostic Medicine, Section of Medical Genetics, University of Ferrara, Ferrara, Italy;(2) Department of Hematology, Universitair Ziekenhuis (UZ) Brussel, Brussels, Belgium;(3) Centre for Reproductive Medicine, Universitair Ziekenhuis (UZ) Brussel, Brussels, Belgium;(4) Department of Reproduction and Genetics, Universitair Ziekenhuis (UZ) Brussel, Brussels, Belgium;(5) Institute for Transfusion Medicine, University Hospital of Essen, Virchowstr. 179, 45122 Essen, Germany; |
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| Abstract: | The nonclassical HLA-G molecule is a trophoblast-specific molecule present in almost every pregnancy. It differs from classical
HLA class I molecules by the low degree of allelic variants and the high diversity of protein structures. HLA-G is reported
to be a tolerogenic molecule that acts on cells of both innate and adaptive immunity. At the maternal–fetal interface HLA-G
seems to be responsible largely for the reprogramming of local maternal immune response. This review will focus on the HLA-G
gene expression profile in pregnancy, in preimplantation embryos, and in human embryonic stem cells with emphasis on the structural
diversity of the HLA-G protein and its potential functional and diagnostic implications. |
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