| 1,4-二取代-1,2,3-三氮唑的合成新方法 |
| |
| 引用本文： | 李海,熊知行. 1,4-二取代-1,2,3-三氮唑的合成新方法[J]. 宁夏大学学报(自然科学版), 2011, 32(2): 147-150 |
| |
| 作者姓名： | 李海 熊知行 |
| |
| 作者单位： | 宜春学院化学与生物工程学院,江西宜春336000;宜春学院,江西省高等学校应用化学与化学生物学重点实验室,江西宜春336000 |
| |
| 基金项目： | 江西省高校重点实验室科技计划基金资助项目(GJJ[2007]431) |
| |
| 摘 要： | 提供一种1,4-二取代-1,2,3-三氮唑的合成新方法.在微波辅助下,碘化亚铜催化叠氮化钠、炔烃和三氟甲磺酸酯合成1,4-二取代-1,2,3-三氮唑.结果表明,在微波功率P=55~70 W,温度为30~50℃下,反应在10 min内完成,产率为79%~93%.该反应产率高、温度低、时间短,对环境无污染.
|
| 关 键 词： | 1,4-二取代-1,2,3-三氮唑 微波合成 三氟甲磺酸酯 |
A New Synthesis for 1,4-Disubstituted-1,2,3-Triazoles |
| |
| Li Haigen,Xiong Zhixing. A New Synthesis for 1,4-Disubstituted-1,2,3-Triazoles[J]. Journal of Ningxia University(Natural Science Edition), 2011, 32(2): 147-150 |
| |
| Authors: | Li Haigen Xiong Zhixing |
| |
| Affiliation: | Li Haigen1,2,Xiong Zhixing1,2(1.College of Chemistry and Bioengineering,Yichun University,Yichun 336000,China,2.Key Laboratory of Jiangxi University for Applied Chemistry and Chemical Biology,China) |
| |
| Abstract: | Triazole is an important organic compound,a new synthetic method for 1,4-disubstituted-1,2,3-triazoles was reported in this paper.A microwave-assisted three-component reaction was used to prepare a series of 1,4-disubstituted-1,2,3-triazoles from corresponding sodium azide,alkynes and trifluoromethane-sulfonates via CuI catalyzed.Controlling microwave power 55-70 W,temperature 30-50 ℃,the reaction was completed in 10 minutes,the yield of 79%-93%.high yield,low temperature,less time cost,and free from pollution to the environment was friendly and safe. |
| |
| Keywords: | 1 4-disubstituted-1 2 3-triazoles microwave synthesis trifluoromethane-sulfonates |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
