| 纳米羟基磷灰石对人牙周膜细胞增殖活性的影响 |
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| 引用本文： | 孙卫斌,吴亚菲,丁一,储成林,刘天佳.纳米羟基磷灰石对人牙周膜细胞增殖活性的影响[J].东南大学学报(自然科学版),2004,34(6):802-805. |
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| 作者姓名： | 孙卫斌 吴亚菲 丁一 储成林 刘天佳 |
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| 作者单位： | 四川大学华西口腔医学院,成都,610064;东南大学材料科学与工程系,南京,210096 |
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| 基金项目： | 江苏省社会发展基金，南京医科大学校科研和教改项目 |
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| 摘 要： | 采用溶胶凝胶法合成纳米羟基磷灰石,透射电镜分析表明其为纳米尺度的材料.应用MTT法对纳米羟基磷灰石和致密羟基磷灰石对体外培养的牙周膜细胞生长进行了分析.结果表明,应用第2,3,4天纳米羟基磷灰石对牙周膜细胞增殖活性有明显促进作用,而致密羟基磷灰石与空白对照组无显著性差异,这说明纳米羟基磷灰石在促进牙周组织再生中有一定的意义.
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| 关 键 词： | 羟基磷灰石 纳米材料 牙周病 |
| 文章编号： | 1001-0505(2004)06-0802-04 |
Influence of nanophase hydroxyapatite on behavior of periodontal ligament cells |
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| Sun Weibin,Wu Yafei,Ding Yi,Chu Ch englin,Liu Tianjia.Influence of nanophase hydroxyapatite on behavior of periodontal ligament cells[J].Journal of Southeast University(Natural Science Edition),2004,34(6):802-805. |
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| Authors: | Sun Weibin Wu Yafei Ding Yi Chu Ch englin Liu Tianjia |
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| Institution: | Sun Weibin1 Wu Yafei1 Ding Yi1 Chu Ch englin2 Liu Tianjia1 |
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| Abstract: | With sol-gel method, the nanophases hydroxyapatite powders were fabricated. These powders were showed to be nanopaticles under transmission electron microscope. The effects on proliferation of periodontal ligament cell(PDLC) were observed in vitro with MTT3-(4, 5-dimethylthiazo;-2-yl)-2, 5-diphenyte tralium bromide] method. The results show that after 2, 3, 4 days treatment with nanoparticles of hydroxyapatite, the proliferative activity of the PDLC increases significantly.In contrast, there is no significant difference between dense hydroxyapatite and control group. Thus, the findings imply that nanophase hydroxyapatite can promote the regeneration of periodontal tissue. |
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| Keywords: | hydroxyapatite nanoparticle materi al periodontal disease |
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