Cell fate determination during G1 phase progression |
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Authors: | V A Blomen J Boonstra |
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Institution: | (1) University College Utrecht, P. O. Box 80145, 3508 TC Utrecht, The Netherlands;(2) Cellular Architecture and Dynamics, Institute of Biomembranes, Padualaan 8, 3584 CH Utrecht, The Netherlands |
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Abstract: | During the cell cycle, a cell may encounter one of five different fates: it can proliferate, differentiate, become quiescent
or senescent, or go into apoptosis. The initiation of such fates is often seen in the G1 phase. The aim of this review is
to describe an integrative model of G1 phase progression and cell fate determination. Along the G1 phase, the cell will encounter
an early checkpoint after which apoptosis can result. For a quiescent state and for differentiation, the cell will exit G1
before the restriction point and a subsequent differentiation checkpoint will decide the fate of the cell, quiescence or differentiation.
After the restriction point, the cell can be arrested in response to stress stimuli, such as telomere depletion, and a decision
between senescence and apoptosis occurs.
Received 19 June 2007; received after revision 23 July 2007; accepted 17 August 2007 |
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Keywords: | Cell cycle quiescence differentiation senescence apoptosis G1 phase |
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