Gene therapy for cancer by mutant HSV deleted apoptosis-inhibited gene |
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Authors: | Lan Ping Qi Yi-peng Xiao Geng-fu |
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Institution: | (1) Institute of Virology, Wuhan University, 430072 Wuhan |
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Abstract: | A mutant HSV (mtHSV) deleted icp34.5, an apoptosis-inhibiting gene was constructed. It is supposed that the mtHSV can replicate
in p53-deficient cells selectively and lead to oncolysis targetedly. Mice tumor model harboring sarcoma cell line s-180 was
developed and the mtHSV was injected into the tumors. We found that the mean volume and weight of tumors of early therapeutic
group(ETG) were reduced 49.29% and 38.31% of that of control tumors. In the mid-term group (MTG), the redutcion rate were
26.9% and 24.52% respectively.
Foundation item: Supported by Foundation of 863 New Hi-technique Research (39880031); Research Fund for the Doctoral Programm
of Higher Education (RFDP98048615); Chen-guang Project of Wuhan City (20005004024).
Biography: Lan Ping (1971-), female, Ph.D candidate, research direction: molecular virology. |
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Keywords: | cancer HSV icp34 5 gene therapy |
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