| 茯苓水提液对小鼠学习记忆的影响 |
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| 引用本文： | 张敏,陈冬雪,孙晓萌. 茯苓水提液对小鼠学习记忆的影响[J]. 北华大学学报(自然科学版), 2012, 13(1): 62-64 |
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| 作者姓名： | 张敏 陈冬雪 孙晓萌 |
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| 作者单位： | 北华大学药学院,吉林吉林,132013;北华大学药学院,吉林吉林,132013;北华大学药学院,吉林吉林,132013 |
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| 基金项目： | 卓怡康纳制药中药研发基金项目(ZY040301) |
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| 摘 要： | 目的研究中药茯苓水提液对小鼠学习记忆的影响.方法通过跳台法观察茯苓水提液对东莨菪碱所致记忆获得障碍模型小鼠和30%乙醇所致记忆再现障碍模型小鼠的影响.结果 1)茯苓水提液能减少东莨菪碱所致记忆获得障碍模型小鼠5 min内学习及记忆实验的错误次数,延长潜伏期,P<0.05,P<0.01,差异有统计学意义.2)茯苓水提液能减少30%乙醇所致记忆再现障碍模型小鼠测试实验中5 min内错误次数,延长潜伏期,P<0.05,P<0.01,差异有统计学意义.结论茯苓水提液能改善化学药物所致学习记忆障碍模型小鼠的学习记忆能力.
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| 关 键 词： | 茯苓水提液 学习记忆 阿尔茨海默病 |
Effects of the Decoction of Poria cocos on Mouse Learning and Memory |
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| ZHANG Min,CHEN Dong-xue,SUN Xiao-meng. Effects of the Decoction of Poria cocos on Mouse Learning and Memory[J]. Journal of Beihua University(Natural Science), 2012, 13(1): 62-64 |
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| Authors: | ZHANG Min CHEN Dong-xue SUN Xiao-meng |
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| Affiliation: | (Pharmacy College of Beihua University,Jilin 132013,China) |
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| Abstract: | Objective To observe the effects of the Decoction of Poria cocos(TDP) on learning and memory dysfunction induced by chemical drugs in mice.Method Effects of TDP on acquired learning and memory disorders induced by scopolamine and reappeared memory disorder induced by 30% alcohol were observed by using step-down test in mice.Results 1)TDP could decrease the numbers of error within 5min and prolong the latency in acquired learning and memory disorders induced by scopolamine.2)TDP could decrease the numbers of error within 5 min and prolong the latency in reappeared memory disorder induced by 30% alcohol.Conclusion TDP would improve mice’s learning and memory dysfunction induced by chemical drugs. |
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| Keywords: | DP learning and memory Alzheimer’s disease |
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