| 基于硅质体的紫杉醇抗癌药物释放系统 |
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| 引用本文： | 戴志飞,薛鹏,梁晓龙.基于硅质体的紫杉醇抗癌药物释放系统[J].黑龙江大学自然科学学报,2011,28(5):696-699. |
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| 作者姓名： | 戴志飞 薛鹏 梁晓龙 |
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| 作者单位： | 哈尔滨工业大学理学院生物医学工程中心纳米医药与生物传感器实验室,哈尔滨,150001 |
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| 基金项目： | 国家自然科学基金资助项目(30970829) |
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| 摘 要： | 设计了一种新型药物载体用以提高紫杉醇载体的稳定性和体外药物缓释性能.首先合成一种新型有机/无机复合脂质,采用薄膜水化法制备空白硅质体,并研究其稳定性；将其装载抗癌药物紫杉醇后,形成紫杉醇硅质体并研究体外药物缓释性能.结果表明:利用新型复合脂质制备的硅质体在表面活性剂环境中具有良好的稳定性；成功将紫杉醇包埋于硅质体中制备...
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| 关 键 词： | 复合脂质 紫杉醇 硅质体 纳米药物载体 药物释放 |
Paclitaxel controlled release system based on novel cerasome |
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| DAI Zhi-fei,XUE Peng,LIANG Xiao-long.Paclitaxel controlled release system based on novel cerasome[J].Journal of Natural Science of Heilongjiang University,2011,28(5):696-699. |
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| Authors: | DAI Zhi-fei XUE Peng LIANG Xiao-long |
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| Institution: | DAI Zhi-fei,XUE Peng,LIANG Xiao-long (Center for Biomedical Engineering,Nanomedicine and Biosensor Laboratory,School of Sciences,Harbin Institute of Technology,Harbin 150001,China) |
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| Abstract: | To design a novel drug carrier in order to improve carrier stability and drug release capacity in vitro.A nanohybrid cerasome was fabricated from a new hybrid lipid by the Bangham method and its stability was studied by surfactant dissolution experiments.Paclitaxel-loaded cerasome was prepared and the drug release behavior was investigated in vitro by a dialytic method.The results suggest that compared to traditional liposome,novel cerasome exhibited remarkable stability in the presence of surfactant.Paclit... |
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| Keywords: | hybrid lipid paclitaxel cerasome nano drug carrier drug release |
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