| 病毒编码的RNA沉默抑制子的特征及其生物技术应用 |
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| 引用本文： | 孙燕霞,刘红梅. 病毒编码的RNA沉默抑制子的特征及其生物技术应用[J]. 山东科学, 2008, 21(2): 21-27 |
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| 作者姓名： | 孙燕霞 刘红梅 |
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| 作者单位： | 山东省烟台市农业科学研究院,烟台,265500;山东农业大学生命科学学院,作物生物学国家重点实验室,泰安,271018 |
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| 基金项目： | 国家自然科学基金 , 山东省优秀中青年科学家科研奖励基金 |
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| 摘 要： | RNA沉默是一种依赖核酸序列特异性的RNA降解过程，是动物、植物抵抗病毒等外源核酸的一种保守防御机制。而针对寄主的这种防御机制，许多病毒演化出RNA沉默抑制子以克服这种防御反应。本文综述了几种动物、植物病毒抑制子的结构和作用方式，讨论了病毒抑制子之间的交叉抑制功能，病毒运动和沉默抑制子之间的关系，病毒RNA和亚病毒寄生物通过沉默抑制子而进行的自我保护原理，抑制子对于miRNA（microRNA）途径的影响以及病毒抑制子在生物技术方面的应用。
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| 关 键 词： | RNA沉默 病毒沉默抑制子 小分子干扰RNA 微RNA |
The Characteristics and Biotechnological Applications of RNA Silencing Suppressors Encoded by Viruses |
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| SUN Yan-xia,LIU Hong-mei. The Characteristics and Biotechnological Applications of RNA Silencing Suppressors Encoded by Viruses[J]. Shandong Science, 2008, 21(2): 21-27 |
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| Authors: | SUN Yan-xia LIU Hong-mei |
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| Affiliation: | SUN Yan-xia, LIU Hong-mei ( 1. Yantai Academy of Agricultural Sciences, Yantai 265500, China ;2. School of Life Science, Shandong Agricultural University, State Key laboratory for Crop Biology, Taian 271018, China ; ) |
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| Abstract: | RNA silencing is a conservative eukaryotic defense mechanism, which is attached to the degradation of exogenous nucleic acid via specific sequences interactions. Viruses have evolved suppressor proteins that help them successfully infect their hosts to counteract it. We perform a survey of structures and effects of some viral suppressors from several plant and animal viruses. We discuss the ability of cross-kingdom suppression of suppressors, the link between movement and silencing suppression, . the self-protection principles of viral RNA and subviral parasites by silencing suppressors, the effects of viral silencing suppressors on the microRNA pathway, and the biotechnological applications of silencing suppressors. |
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| Keywords: | RNA silencing viral silencing suppressor short interfering RNA microRNA |
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