Effects of calcineurin on LTP of rats <Emphasis Type="Italic">in vivo</Emphasis> |
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Authors: | Jie?Luo Ailin?Lou Email author" target="_blank">Qun?WeiEmail author |
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Institution: | (1) Department of Biochemistry and Molecular Biology, Beijing Normal University, 100875 Beijing, China;(2) Department of Physiology Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, 100020 Beijing, China |
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Abstract: | Calcineurin (CN) is thought to play a role in the synaptic plastivity and long-term potentiation (LTP) in the hippocampus.
Based on two LTP models in vivo, a specific inhibitor cyclosporin A (CsA) of CN was observed, which affected LTP in the hippocampal dentate gyrus of the
rats. The results indicated that CsA blocked LTP induced by high frequency stimulation (HFS) partly, but it had no effect
on the decrease of the onset and peak latency of population spikes (PS) except that it reduced the increase of the amplitude
after HFS. On the other hand, CsA blocked LTP induced by ginsenosides (GSS) completely. It suppressed the GSS-enhanced amplitude
of PS reversibly and blocked the decrease of the peak latency of PS induced by the GSS. These results suggest that the postsynaptic
CN plays a role in the induction of LTP in the hippocampus of the rats. |
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Keywords: | calcineurin cyclosporin A hippocampus long term potentiation (LTP) ginsenosides |
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