Changes in blood-brain permeability resulting from d-amphetamine, 6-hydroxydopamine and pimozide measured by a new technique

Summary A new technique is described for measurement of diffusion across the blood-brain barrier using intraventricularly administered⁶⁸Ga-EDTA, and determining loss from the brain with a scintillation camera. Repeated injections via permanent cannulas showed that the diffusion half-time was reduced to 50% of control values after intraventricular d-amphetamine and 6-hydroxydopamine; pimozide had no effect.Acknowledgment. This work was supported by the Division of Biomedical and Environmental Research of the US Department of Energy, and the Deutsche Forschungsgemeinschaft.