疏水化长脂肪链酰化壳聚糖的制备

以氯仿、吡啶为反应介质，制备出完全疏水化的长脂肪链酰化壳聚糖，并研究反应条件对酰化取代度的影响．实验结果表明，壳聚糖在高吡啶／氯仿体积比介质中酰化度高，分子量低的壳聚糖取代度高，壳聚糖的酰化度还随着酰卤脂肪链长度的增加而呈下降的趋势．最后，产物用元素分析、红外光谱、核磁共振和热分析进行表征．

Preparation of Hydrophobing Acyl Chitosan with Long Fatly Chain

Using chloroform and pyridine as reaction medium, the authors prepare fully hydrophobing acyl chitosan with long fatly chain; and study the effect of reaction condition on degree of acyl substitution. As indicated by experimental resuits, chitosan shows high degree of acylation in the medium with high pyridine/chloroform volume ratio, and chitosan with low molecular weight shows high degree of substitution. The degree of acylation of chitosan tends to decrease with the increasing length of acyl halide fatty chain. The products are characterized by using elementary analysis, infrared spectrum, nuclear magnetic resonance and thermoanalysis.