| 醇酒酵母反义snoRNA一级结构的分析 |
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| 引用本文： | 岳强,周惠,屈良鹄.醇酒酵母反义snoRNA一级结构的分析[J].中山大学学报(自然科学版),2001,40(1):68-72. |
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| 作者姓名： | 岳强 周惠 屈良鹄 |
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| 作者单位： | 中山大学生物工程研究中心, |
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| 基金项目： | 国家自然科学基金资助项目(39970171)；广东省自然科学基金资助项目(990242) |
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| 摘 要： | 对酿酒酵母Saccharomyces cerevisiae基因组中发现和鉴定的41个反义snoRNA进行一级结构的分析表明：酿酒酵母snoRNA基因富含AT：41个反义snoRNA全都有boxC'和boxD'结构元素；根据反义snoRNA保守结构元素及反义序列的数目和位置的特点，将反义snoRNA分为5种结构类型，认为snoRNA具有两个主要的功能区；在snR57、snR59、snR71和snR75不具有指导甲基化反义序列的功能区中，发现有一段长10－12个核苷酸的序列与rRNA互补，为进一步研究反义snoRNA的结构与功能提供了重要线索。
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| 关 键 词： | 醇酒酵母 反义SNORNAG 一级结构 反义序列 结构元素 重复序列 SNORNA基因 |
| 文章编号： | 0529-6579(2001)01-0068-05 |
| 修稿时间： | 2000年9月4日 |
Primary Structural
Analysis of Saccharomyces cerevisiae Antisense snoRNAs |
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| YUE Qiang,ZHOU Hui,QU Liang-hu.Primary Structural
Analysis of Saccharomyces cerevisiae Antisense snoRNAs[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2001,40(1):68-72. |
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| Authors: | YUE Qiang ZHOU Hui QU Liang-hu |
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| Abstract: | The primary structure of the 41 antisense snoRNAs from Saccharomyces cerevisiae were analyzed. The re-sults show that S. cerevisiae snoRNAs are AT-rich. The 41 antisense snoRNAs all possess the structure elements of boxC and boxD and they can be divided into five group according to the conserved structural element and the number or position of antisense sequence, suggesting two major functional regions within the snoRNA genes. Another 10 -12 nucleotide sequence, which is complementary to rRNA, was found in snR57, snR59, snR68, snR7l and snR75 respectively, these sequences are supposed to have unknown function instead of guiding rRNA methylation. The findings would be helpful to elucidate the relationship between structure and function of antisense snoRNA. |
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| Keywords: | Saccharomyces cerevisiae antisense snoRNA primary structure antisense sequence |
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