| EGCG对肿瘤干细胞抑制效应研究进展 |
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| 引用本文： | 陈磊,李开鸣,马会景,曾宪思,贾金婧,宋新强. EGCG对肿瘤干细胞抑制效应研究进展[J]. 信阳师范学院学报(自然科学版), 2018, 0(1): 145-151 |
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| 作者姓名： | 陈磊 李开鸣 马会景 曾宪思 贾金婧 宋新强 |
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| 作者单位： | 信阳师范学院生命科学学院;信阳师范学院河南省茶树生物学重点实验室;信阳师范学院图书馆; |
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| 摘 要： | 表没食子儿茶素没食子酸酯((-)-Epigallocatechin-3-gallate,EGCG)是绿茶主要活性成分之一,对肿瘤干细胞(Cancer stem cells,CSCs)具备抑制效应.综述了EGCG对CSCs迁移侵袭性、耐药性、自我更新和致瘤性等病理学特性的抑制效应及应用新策略,并对相应信号传导通路进行阐述,为深入研究EGCG抗癌的药理学效应及应用新策略提供借鉴.
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| 关 键 词： | EGCG 肿瘤干细胞 自我更新 迁移性 致瘤性 综述 |
Progress in EGCG Functioned on Cancer Stem Cells |
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| Affiliation: | ,College of Life Sciences,Xinyang Normal University,Tea Plant Biology Key Laboratory of Henan Province,Xinyang Normal University,Library,Xinyang Normal University |
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| Abstract: | (-)-Epigallocatechin-3-gallate(EGCG),a major bioactive constituent in green tea,possesses anticarcinogenic potential in different tumors.Recent data also showed that EGCG displayed its anti-cancer activity by targeting CSCs.This review focusses on the studies of EGCG functioned on characteristics,including migration and invasion,anti-chemotherapy,self-renewal and tumorigenicity.In addition,signaling pathways,including Wnt/β-catenin,Hedgehog,Notch and AKT pathways,involved in these progress were discussed to provide options for cancer and treatment. |
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| Keywords: | EGCG cancer stem cells self-renewal migratory tumorigenicity review |
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