Hypertension mediated by the activation of the rat brain 5-hydroxytryptamine receptor sites |
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| Authors: | M K Krsti? Draginja Djurkovi? |
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| Institution: | (1) Department of Pharmacology, Faculty of Medicine, P. O. Box 662, 11000 Beograd, (Yugoslavia) |
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| Abstract: | Summary 5-Hydroxytryptamine (5-HT) administered intraventricularly (i.vent.) in rats produced hypertension without considerable changes in heart rate. After transsection of the spinal cord or i.vent. administration of methysergide, 5-HT failed to produce the pressor effect. Thus, the hypertension results from the activation of 5-HT receptor sites of the rat brain.This work was supported by Union of Scientific Medical Institutions of Serbia (Grant No. 85). |
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