Effects of bicuculline and chlordiazepoxide on locomotor activity and avoidance performance in rats |
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Authors: | V Cuomo I Cortese |
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Institution: | (1) Institute of Pharmacology, University of Bari, I-70124 Bari, (Italy) |
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Abstract: | Summary Bicuculline, at a dose of 1 mg/kg which, per se, failed to change locomotor activity in rats, counteracts the facilitating effect induced by chlordiazepoxide (10 mg/kg). Conversely, bicuculline (1 mg/kg) does not modify the decrease of motor activity and the disruption of avoidance performance induced by this benzodiazepine derivative (20 mg/kg). |
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