| N-芳基-4-碘吡唑与芳基二硫醚的偶联反应 |
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| 引用本文： | 陈叶娜,钟平. N-芳基-4-碘吡唑与芳基二硫醚的偶联反应[J]. 温州大学学报(自然科学版), 2010, 31(2): 26-29. DOI: 10.3875/j.issn.1674-3563.2010.02.006 |
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| 作者姓名： | 陈叶娜 钟平 |
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| 作者单位： | 温州大学化学与材料工程学院,浙江温州,325035 |
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| 基金项目： | 国家自然科学基金，浙江省自然科学基金，浙江省科技计划重点项目 |
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| 摘 要： | 1-(2,6-二氯-4-三氟甲基苯基)-3-氰基-5-氨基吡唑经碘代反应合成4-碘-1-(2,6-二氯-4-三氟甲基苯基)-3-氰基-5-氨基吡唑(N-芳基-4-碘吡唑).以N,N'-二甲基乙二胺为配体,在CuI催化下,N-芳基-4-碘吡唑与芳基二硫醚偶联反应,制备了N-芳基-4-芳硫基吡唑,产率75%-82%.最后通过1H NMR、13C NMR、IR、MS对产物结构进行了表征.
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| 关 键 词： | N-芳基4碘吡唑 芳基二硫醚 偶联反应 碘化亚铜 |
Coupling Reaction of N-Aryl-4-iodopyrazole and Aryl Disulfides |
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| CHEN Yena,ZHONG Ping. Coupling Reaction of N-Aryl-4-iodopyrazole and Aryl Disulfides[J]. Journal of Wenzhou University Natural Science, 2010, 31(2): 26-29. DOI: 10.3875/j.issn.1674-3563.2010.02.006 |
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| Authors: | CHEN Yena ZHONG Ping |
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| Affiliation: | CHEN Yena,ZHONG Ping(College of Chemistry , Materials Engineering,Wenzhou University,Wenzhou,China 325035) |
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| Abstract: | 4-iodo-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-aminopyrazole(N-aryl-4-iodopyrazole) was synthesized from 1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-aminopyrazole by iodination.N-aryl-4-arylthiopyrazole was synthesized from N-aryl-4-iodopyrazole and aryl disulfides by coupling reaction using N,N'-dimethylaminoethylamine as ligand and CuI as catalyst.The rate of production was in the range of 75% to 82%.The structure of the product was characterized by 1H NMR,13C NMR,IR and MS spectra. |
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| Keywords: | N-aryl-4-iodopyrazole Aryl Disulfides Coupling Reaction Cuprous Iodide(CuI) |
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