| Synthesis and characterization of nanoscale magnetic drug-inorganic composites |
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| 作者姓名： | SUNHui ZHANGHui DavidG.Evans DUANXue |
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| 作者单位： | MinistryofEducationKeyLaboratoryofScienceandTechnologyofControllableChemicalReactions,BeijingUniversityofChemicalTechnology,Beijing100029,China |
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| 摘 要： | The synthesis by direct coprecipitation and characterization of captopril (Cpl) and 5-aminosalicylic acid(5-ASA) intercalated ZnAI layered double hydroxides coated on MgFe2O4 magnetic core particles are reported. Powder XRD analysis shows the well-defined crystallite structure of the composites. TEM and XPS results reveal that a core-shell structure involving a drug-LDHs layer coated on MgFe2O4 particles is formed through Zn-O-Mg and/or Al-O-Mg linkages. VSM measurements demonstrate that the novel magnetic drug-inorganic composites possess considerable magnetization.
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| 关 键 词： | 磁性指标药物 锌铝分层 氢氧化物 沉淀物 |
| 收稿时间： | 2004-07-22 |
Synthesis and characterization of nanoscale magnetic drug-inorganic composites |
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| SUNHui ZHANGHui DavidG.Evans DUANXue.Synthesis and characterization of nanoscale magnetic drug-inorganic composites[J].Chinese Science Bulletin,2005,50(8):752-757. |
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| Authors: | Hui Sun Hui Zhang David G Evans Xue Duan |
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| Institution: | SUN Hui, ZHANG Hui, David G. Evans & DUAN Xue Ministry of Education Key Laboratory of Science and Technology of Controllable Chemical Reactions, Beijing University of Chemical Tech- nology, Beijing 100029, China |
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| Abstract: | The synthesis by direct coprecipitation and characterization of captopril (Cpl) and 5-aminosalicylic acid (5-ASA) intercalated ZnAl layered double hydroxides coated on MgFe2O4 magnetic core particles are reported. Powder XRD analysis shows the well-defined crystallite structure of the composites. TEM and XPS results reveal that a core-shell structure involving a drug-LDHs layer coated on MgFe2O4 particles is formed through Zn-O-Mg and/or Al-O-Mg link- ages. VSM measurements demonstrate that the novel mag- netic drug-inorganic composites possess considerable mag- netization. |
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| Keywords: | magnetic targeted drug zinc aluminum layered double hydroxide captopril 5-aminosalicylic acid coprecipitation core- shell structure |
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