| 一种2,5–取代的吡啶类药物中间体的合成 |
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| 引用本文： | 郑清云,邝代宏,张向阳. 一种2,5–取代的吡啶类药物中间体的合成[J]. 湖南文理学院学报(自然科学版), 2015, 0(1): 42-44. DOI: 10.3969/j.issn.1672-6146.2015.01.010 |
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| 作者姓名： | 郑清云 邝代宏 张向阳 |
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| 作者单位： | 湖南文理学院 化学化工学院,湖南 常德,415000 |
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| 摘 要： | 吡啶衍生物因其独特的化学结构,已被作为一类合成子广泛地应用于药物中间体的构建。以2,5–吡啶二甲酸二甲酯为原料,通过水解、酰化和还原等反应合成了一种新的2,5–取代的吡啶类药物中间体。
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| 关 键 词： | 吡啶类化合物 2, 5-吡啶二甲酸二甲酯 药物中间体 合成 |
Study on the synthesis of a new 2, 5-substituted quinoline intermediates for pharmacology |
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| Zheng Qingyun;Kuang Daihong;Zhang Xiangyang. Study on the synthesis of a new 2, 5-substituted quinoline intermediates for pharmacology[J]. Journal of Hunan University of Arts and Science:Natural Science Edition, 2015, 0(1): 42-44. DOI: 10.3969/j.issn.1672-6146.2015.01.010 |
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| Authors: | Zheng Qingyun Kuang Daihong Zhang Xiangyang |
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| Affiliation: | Zheng Qingyun;Kuang Daihong;Zhang Xiangyang;College of Chemistry and Chemical Engineering, Hunan University of Arts and Science; |
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| Abstract: | Because of their unique chemical structures, pyridine derivatives have been widely used in pharmaceutical intermediates as a synthon. Dimethyl 2, 5-Pyridinedicarboxylate as raw material, through hydrolysis, acylation and reduction reaction, a new 2, 5-substituted pyridine pharmaceutical intermediate is synthesized. |
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| Keywords: | pyridine derivatives dimethyl 2,5-pyridinedicarboxylate drug intermediate synthesis |
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