| 新型4–羟基喹啉衍生物的合成 |
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| 引用本文： | 张向阳,康秀芝,申有名,张春香.新型4–羟基喹啉衍生物的合成[J].湖南文理学院学报(自然科学版),2015(1):38-41. |
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| 作者姓名： | 张向阳 康秀芝 申有名 张春香 |
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| 作者单位： | 湖南文理学院 化学化工学院，湖南 常德，415000 |
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| 基金项目： | 湖南文理学院博士启动基金(10305005);湖南文理学院校级重点项目(13ZD08);湖南省十二五重点建设学科—应用化学资助 |
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| 摘 要： | 以米食酸、原甲酸三甲酯、苯胺类化合物和氯甲酸苄酯为原料,通过2条合成路线,以中等的收率制备了3种结构新颖的4–羟基喹啉衍生物,并利用核磁共振谱图对目标化合物进行了表征。另外,考察了取代基对目标化合物合成的影响,只有氨基的邻位有取代基时,才能制备所设计的目标化合物。
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| 关 键 词： | 喹啉衍生物 环化反应 结构互变 新合成方法 |
Study on the synthesis of 4-hydroxyquinoline derivatives |
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| Zhang Xiangyang;Kang Xiuzhi;Shen Youming;Zhang Chunxiang.Study on the synthesis of 4-hydroxyquinoline derivatives[J].Journal of Hunan University of Arts and Science:Natural Science Edition,2015(1):38-41. |
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| Authors: | Zhang Xiangyang;Kang Xiuzhi;Shen Youming;Zhang Chunxiang |
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| Institution: | Zhang Xiangyang;Kang Xiuzhi;Shen Youming;Zhang Chunxiang;College of Chemistry and Chemical Engineering, Hunan University of Arts and Science; |
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| Abstract: | Three kinds of novel 4-hydroxyquinoline derivatives with medium yield are obtained through two routes, using eat rice acid, trimethyl orthoformate, aniline compounds and benzyl ester as raw materials. The spectra of target compounds are characterized by NMR. In addition, the effect of substituents on the synthetic compounds is investigated. When the substituent at ortho positionat of amino atom, the target compound can be successfully synthesized. |
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| Keywords: | quinoline derivatives cyclization reaction tautomerism new synthetic method |
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