| 5,7-二羟基黄酮的合成工艺改进 |
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| 引用本文： | 蔡小华,胡薇. 5,7-二羟基黄酮的合成工艺改进[J]. 上饶师范学院学报, 2004, 24(6): 59-60 |
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| 作者姓名： | 蔡小华 胡薇 |
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| 作者单位： | 1. 怀化医学高等专科学校药学系,湖南,怀化,418000
2. 南昌大学分析测试中心,江西,南昌,330000 |
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| 基金项目： | 浙江省自然科学基金资助项目(20010207) |
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| 摘 要： | 间苯三酚(2)与乙腈发生Hoesch反应，合成中间体2’，4’，6’-三羟基苯乙酮(3)；然后在相转移催化剂TEBA存在下，与苯甲酰氯缩合，得到中间体1-(2’，4’，6’-三羟苯基)-3-苯基-1，3-丙二酮(4)，4不经过分离，一锅法直接重排和关环合成5’，7’-二羟基黄酮(1)，总收率为68．4％，比文献提高8％。
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| 关 键 词： | 二羟基 合成工艺 中间体 环合 总收率 苯甲酰氯 缩合 苯乙酮 一锅法 间苯三酚 |
| 文章编号： | 1004-2237(2004)06-0059-02 |
| 修稿时间： | 2004-04-26 |
Synthetic Study on 5,7-dihydroxyflavone |
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| CAI Xiao-Hua,HU Wei. Synthetic Study on 5,7-dihydroxyflavone[J]. Journal of Shangrao Normal College, 2004, 24(6): 59-60 |
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| Authors: | CAI Xiao-Hua HU Wei |
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| Affiliation: | CAI Xiao-Hua~1,HU Wei~2 |
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| Abstract: | The intermediate 2', 4', 6'-trihydroxyacetophenone(3) was gained from phlorglucinol reacted with carbonitrile Hoesch reaction. 3 was condensed with benzoyl chloride and the intermediate of 1-(2', 4', 6'-hydroxyphenyl)-3-propane-3, 4-dione(4) was obtained at the point of phase transfer catalyst TEBA. 4 rearrange and closed cycle directly and then 5', 7'-dihydroxyflavone(1)was synthesized at one-pot. The total yield is 68.4% and increased 8% compared with literature |
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| Keywords: | dihydroxyflavone 2' 4' 6'-trihydroxyacetophenone 1-(2' 4' 6'-trihydroxy phenyl)-3- phenyl propane-1 3-dione phlorglucinol |
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