| RNAi表达载体在哺乳动物中的研究进展 |
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| 引用本文： | 侯莹,成志云,王立强,许瑞安,唐明青. RNAi表达载体在哺乳动物中的研究进展[J]. 华侨大学学报(自然科学版), 2015, 0(3): 314-320. DOI: 10.11830/ISSN.1000-5013.2015.03.0314 |
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| 作者姓名： | 侯莹 成志云 王立强 许瑞安 唐明青 |
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| 作者单位： | 华侨大学 生物医学学院, 福建 泉州 362021 |
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| 基金项目： | 国家高技术研究发展计划(863计划)资助项目(2012AA020810)；国家自然科学基金资助项目(81271692)；福建省中青年教师教育科研项目(JA14020)；中央高校基本科研业务费专项资金资助项目(JB-JC1004)；华侨大学人才引进项目 |
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| 摘 要： | 对RNA干扰(RNAi)表达载体的非生物与生物递送系统及主流应用进行综述,明确其在基因调控及未来基因治疗领域的应用前景,并指出其在种属特异性及表达效率等方面存在的局限性.对RNAi表达载体的结构组成、发展沿革及体内作用机制进行归纳分析,提出基于结构组成和加工机制双重属性的分类方法.
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| 关 键 词： | RNA干扰 表达载体 短发夹式RNA载体 微小RNA载体 哺乳动物 |
Research Progress of RNA Interference Expression Vector in Mammals |
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| HOU Ying,CHENG Zhi-yun,WANG Li-qiang,XU Rui-an,TANG Ming-qing. Research Progress of RNA Interference Expression Vector in Mammals[J]. Journal of Huaqiao University(Natural Science), 2015, 0(3): 314-320. DOI: 10.11830/ISSN.1000-5013.2015.03.0314 |
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| Authors: | HOU Ying CHENG Zhi-yun WANG Li-qiang XU Rui-an TANG Ming-qing |
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| Affiliation: | School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China |
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| Abstract: | This paper reviewed the non-biological and biological delivery systerms of RNA interference expression vector as well as the major applications, and cleared the application prospect in the area of gene regulation and gene therapy in the future, and also pointed out the limitation in the species-specificity and expression efficiency etc. This paper summarized and analyzed the structure composition and development evolution of the RNAi expression vector as well as the function mechanism in vivo, and proposed the classification based on the dual attributes of structure composition and processing mechanism. |
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| Keywords: | RNA interference expression vector small hairpin RNA vector microRNA vector mammals |
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