Endocrine control of lysosomal alterations in rat liver during the perinatal period |
| |
Authors: | D Bal R Vaillant |
| |
Institution: | (1) Lab. de Physiologie comparée, Université Pierre-et-Marie-Curie, 9, quai Saint-Bernard, F-75230 Paris;(2) Lab. d'Endocrinologie, F-76130 Mont Saint-Aignan, (France) |
| |
Abstract: | Summary Within hours of birth, some physical properties of liver lysosomes are modified. These alterations, which may be related to the autophagic vacuoles formation known to occur during this period, were inhibited by insulin administration. Glucagon, a potent inducer of autophagy in adult rat liver, did not anticipate this process in fetal liver. Our results suggest that the decrease of plasma insulin immediately after birth is a important factor in the development of hepatic autophagy. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|