| 作为潜在抗癌试剂的单取代(环氧丙烷氨基)蒽醌的合成 |
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| 引用本文： | 张昱,卢俊瑞.作为潜在抗癌试剂的单取代(环氧丙烷氨基)蒽醌的合成[J].天津理工大学学报,2006,22(1):13-15. |
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| 作者姓名： | 张昱 卢俊瑞 |
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| 作者单位： | 天津理工大学,生物与化学工程学院,天津,300191 |
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| 摘 要： | Zee-Cheng and coworkers first prepared effica-cious antitumor agent M itoxantrone by leuco-1,4,5,8-tetrahydroxyanthraquinone reacting with 2-(2-am in-oethylam ino)ethanol,and they proposed structure-ac-tivity relationship(SAR)of anthraquinones as antitu-m…
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| 关 键 词： | 1-(环氧丙烷氨基)蒽醌 N-烷基化反应 酸催化 闭环反应 1-(3-氯-2羟-基丙氨基)蒽醌 |
| 文章编号： | 1673-095X（2006）01-0013-03 |
| 收稿时间： | 2005-10-21 |
| 修稿时间： | 2005年10月21 |
Synthesis of mono- (epoxypropylamino) anthraquinone derivatives as potent antitumor agents |
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| ZHANG Yu,LU Jun-rui.Synthesis of mono- (epoxypropylamino) anthraquinone derivatives as potent antitumor agents[J].Journal of Tianjin University of Technology,2006,22(1):13-15. |
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| Authors: | ZHANG Yu LU Jun-rui |
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| Institution: | School of Biological and Chemical Engineering, Tianjin University of Technology, Tianjin 300191, China |
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| Abstract: | 1-(epoxypropylamino)anthraquinonewas synthesizedfrom 1-aminoanthraquinone I and by N-alkylation reaction,being treated with epoxy compounds such as epichlorohydrin,and then the ring-closing of side chain3-chloro-2-hydroxypropylamino-formed oxirane ring in the side chain in the course of their work-up by alkali aqueous solutions.The immediate 1-(3-chloro-2-hydroxypropylamino)anthraquinonereacting with water under base catalyst,and fatty amine wereinvestigated. |
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| Keywords: | 1-(epoxypropylamino) anthraquinone N-alkylation acid catalyst ring closing reaction 1-(3-chloro-2-hydroxypropylamino) anthraquinone |
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