Annexin A5: shifting from a diagnostic towards a therapeutic realm |
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Authors: | H Kenis L Hofstra C P M Reutelingsperger |
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Institution: | (1) Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands |
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Abstract: | The surge in apoptosis research and the discovery of the phosphatidylserine binding properties of annexin A5 have propelled
a tremendous interest in cell death detection technologies. In the past years, annexin A5 has evolved from an efficient assay
for detection of apoptotic cells in vitro to an in vivo molecular imaging technology with potential clinical use. A second key discovery, the specific internalization properties
of annexin A5, has opened the opportunity to use annexin A5 for therapeutic applications. Annexin A5-mediated internalization
creates a novel therapeutic platform for targeted drug delivery and cell entry to treat various diseases, including cancer
and cardiovascular disease.
Received 29 June 2007; received after revision 19 July 2007; accepted 15 August 2007 |
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Keywords: | Annexin A5 phosphatidylserine apoptosis diagnosis therapy |
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