首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Annexin A5: shifting from a diagnostic towards a therapeutic realm
Authors:H Kenis  L Hofstra  C P M Reutelingsperger
Institution:(1) Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
Abstract:The surge in apoptosis research and the discovery of the phosphatidylserine binding properties of annexin A5 have propelled a tremendous interest in cell death detection technologies. In the past years, annexin A5 has evolved from an efficient assay for detection of apoptotic cells in vitro to an in vivo molecular imaging technology with potential clinical use. A second key discovery, the specific internalization properties of annexin A5, has opened the opportunity to use annexin A5 for therapeutic applications. Annexin A5-mediated internalization creates a novel therapeutic platform for targeted drug delivery and cell entry to treat various diseases, including cancer and cardiovascular disease. Received 29 June 2007; received after revision 19 July 2007; accepted 15 August 2007
Keywords:Annexin A5  phosphatidylserine  apoptosis  diagnosis  therapy
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号