Phase response curve to anisomycin intau mutant hamsters |
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Authors: | N Mrosovsky M R Ralph |
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Institution: | (1) Departments of Zoology, Psychology and Physiology, University of Toronto, M5S 1A1 Toronto, Ontario, Canada |
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Abstract: | Administration of the protein synthesis inhibitor, anisomycin, to wild type hamsters produces phase shifts in their circadian rhythms that have similarities to shifts produced by non-photic behavioral stimulation. A mutation that shortens the period of rhythms in hamsters results in altered responsiveness to non-photic input. However, responses of the mutants to anisomycin are unaffected: their phase response curve (PRC) for anisomycin is similar to that of wild types. This suggests that 1) anisomycin is not acting on mechanisms specifically involved in non-photic behavioral phase shifting, and 2) the mutation affects the non-photic input pathway or the pacemaker itself at a point that is upstream from anisomycin's site of action. |
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Keywords: | Activity anisomycin hamster non-photic phase response curve protein synthesis rhythms |
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