Pervasive roles of microRNAs in cardiovascular biology |
| |
Authors: | Small Eric M Olson Eric N |
| |
Affiliation: | Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA. |
| |
Abstract: | First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wideranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|