| 双亲性两嵌段共聚物膜与胶束融合机制的研究 |
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| 引用本文： | 王玲,张海珍,刘天成,杨恺.双亲性两嵌段共聚物膜与胶束融合机制的研究[J].云南民族大学学报(自然科学版),2014,23(5):326-330. |
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| 作者姓名： | 王玲 张海珍 刘天成 杨恺 |
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| 作者单位： | 1. 苏州大学软凝聚态物理及交叉研究中心,江苏苏州,215006
2. 云南民族大学云南省生物高分子功能材料工程技术研究中心,云南昆明,650500 |
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| 基金项目： | 国家自然科学基金，教育部科学技术研究重点项目，云南省应用基础研究计划 |
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| 摘 要： | 为了理解胶束向细胞输送药物过程中两者的相互作用机制,特别是两者融合的过程,使用分子动力学(MD)方法研究了双亲性两嵌段共聚物膜与共聚物胶束的相互作用机制.发现胶束与共聚物膜之间的距离、组成胶束的聚合物的数目等因素会强烈影响两者的融合.对于不同大小的胶束,其与共聚物膜融合的可能性会随着初始间距的变化而呈现出复杂的变化.结果表明:胶束的大小可以对其药物输运的效率产生影响.
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| 关 键 词： | 双亲性嵌段共聚物膜 胶束 融合 |
Conputer simulations on the interaction mechanism between an amphiphilic copolymer bilayer membrane and micelle |
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| WANG Ling,ZHANG Hai-zhen,LIU Tian-cheng,YANG Kai.Conputer simulations on the interaction mechanism between an amphiphilic copolymer bilayer membrane and micelle[J].Journal of Yunnan Nationalities University:Natural Sciences Edition,2014,23(5):326-330. |
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| Authors: | WANG Ling ZHANG Hai-zhen LIU Tian-cheng YANG Kai |
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| Institution: | WANG Ling;ZHANG Hai-zhen;LIU Tian-cheng;YANG Kai;Center for Soft Condensed Matter Physics and Interdisciplinary Research,Soochow University;Engineering Research Center of Biopolymer Functional Materials of Yunnan,Yunnan Minzu University; |
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| Abstract: | In order to investigate the interaction mechanism between an amphiphilic copolymer bilayer membrane and micelle,including the fusion between them,molecular dynamics( MD) is used to simulate the interaction between amphiphilic copolymer bilayer membrane and copolymer micelle. It is found that the fusion between the micelle and the membrane is influenced by the distance between them as well as the amount of copolymer molecules composing the micelle. It is indicated by our simulations that the size of the micelle could be an effective way to control the efficiency of drug delivery of micelle to cells. |
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| Keywords: | amphiphilic copolymer bilayer membrane micelle fusion |
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