The structure of an oligo(dA).oligo(dT) tract and its biological implications |
| |
| Authors: | H C Nelson J T Finch B F Luisi A Klug |
| |
| Institution: | Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. |
| |
| Abstract: | Poly(dA).poly(dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A.T base pairs shows that this region possesses special structural features, including a system of bifurcated hydrogen bonds, which explains some of the properties of this simple homopolymer. |
| |
| Keywords: | |
|
|
