植物素对小鼠酒精中毒血清酶及超微结构影响

以昆明小鼠为材料，研究了解酲营养素对小鼠肝酒精中毒的血清酶及超微结构的影响。结果表明，解梧营养素能明显降低酒精引起的小鼠血清ＧＰＴ的升高，电镜观察显示，饮酒组，肝细胞结构严重损，其线粒体重度肿胀，粗面内质网扩张严重，溶酶体减少并有大量脂肪滴分布。实验组小鼠其肝细胞中有稀疏的脂肪滴；细胞电子密度接近正常肝细胞；线粒体基质密度轻度降低。

THE EFFECTS OF JIECHENG NUTRIENT ON THE SERUM ENZYME ACTIVITY AND ULTRASTURCTURE CHANGE OF ALCOHOLISMED MOUSE

The effects of jiecheng nutrient (extracts of some chinese traditional drug plants)on the serum enzyme activity and ultrastructure changes of alcoholismed mouse were studied.The results demonstrated that jiecheng nutrient could obviously derease the raise of serum GTP activity induced by alcohol. The ultrastructure of liver cells has shown that in alcohol treated group, the structures of mouse liver cells were seriously damaged;the mitochondria were swollen, the rough endoreticulum was enlarged, and the cytoplasm was fillen with a lot of large lipidd granules. In jiecheng nutrint trearted group, the ultrastructure of the liver cells were lightly changed; there were very little lipid granulles in the cytoplasm matrix,the density of electon was as same as that in the normal cell, the matrix of mitochondria shown lightly decrease,the amount of rough endoreticulum increased and the rugh endoreticulum were slightly swollen on which the ribosome were well-distributed, the amount of lysosomes were also increased, but the structure of nuleus showed no changes, the electron density of cytoplasm matrix was medial. In the contral group(only given jiecheng nutrint),the ultrastructures of liver cells had no changes.