Biogenesis of bacterial inner-membrane proteins |
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Authors: | Sandra J Facey Andreas Kuhn |
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Institution: | (1) Institute of Microbiology, University of Hohenheim, 70599 Stuttgart, Germany; |
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Abstract: | All cells must traffic proteins into and across their membranes. In bacteria, several pathways have evolved to enable protein
transfer across the inner membrane, the periplasm, and the outer membrane. The major route of protein translocation in and
across the cytoplasmic membrane is the general secretion pathway (Sec-pathway). The biogenesis of membrane proteins not only
requires protein translocation but also coordinated targeting to the membrane beforehand and folding and assembly into their
protein complexes afterwards to function properly in the cell. All these processes are responsible for the biogenesis of membrane
proteins that mediate essential functions of the cell such as selective transport, energy conversion, cell division, extracellular
signal sensing, and motility. This review will highlight the most recent developments on the structure and function of bacterial
membrane proteins, focusing on the journey that integral membrane proteins take to find their final destination in the inner
membrane. |
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Keywords: | |
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