Comparison of the ototoxic effect of kanamycin on albino and pigmented rats,studied using an operant method |
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| Authors: | E S Harpur P F D'Arcy |
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| Institution: | (1) Department of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL Belfast, (Northern Ireland);(2) Present address: Department of Pharmacy, The University of Aston in Birmingham, Gosta Green, B4 7ET Birmingham, England |
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| Abstract: | Summary A study was made of the effect of daily administration of kanamycin (400 mg kg–1) on the hearing of Wistar albino and Lister hooded (pigmented) rats, which had been conditioned to discriminate an acoustic signal. In all animals except one, the drug caused severe, permanent hearing impairment and there was no difference between albino and pigmented rats in onset or degree. Other work has suggested a mediatory role for melanin pigment in such drug ototoxicity but the significance of this must be questioned in view of the failure to find any differences in functional deficit.This work was supported by a Fellowship toE. S. Harpur from the Department of Health and Social Services (Northern Ireland). |
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