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Validating cancer drug targets
Authors:Benson John D  Chen Ying-Nan P  Cornell-Kennon Susan A  Dorsch Marion  Kim Sunkyu  Leszczyniecka Magdalena  Sellers William R  Lengauer Christoph
Affiliation:Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Abstract:A cancer drug target is only truly validated by demonstrating that a given therapeutic agent is clinically effective and acts through the target against which it was designed. Nevertheless, it is desirable to declare an early-stage drug target as 'validated' before investing in a full-scale drug discovery programme dedicated to it. Although the outcome of validation studies can guide cancer research programmes, strictly defined universal validation criteria have not been established.
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