草酸铂联合方案一线治疗晚期胃癌的临床研究

目的 研究草酸铂联合吡柔比星和氟脲嘧啶／甲酰四氢叶酸钙一线治疗晚期胃癌的疗效和毒副反应．方法 草酸铂135mg／m^2，静脉滴注3h．第1天；吡柔比星35mg／m^2静脉推注,第1天;甲酰四氢叶酸钙200mg／d，静脉滴注2h，第1至第5天;氟脲嘧啶400mg／m^2，静脉滴注,第1至第5天,28d为1周期．结果共治疗56例患者．完全缓解4例，部分缓解26例，稳定20例，进展6例，有效率为53．6％．至疾病进展中位时间为4．5个月．主要不良反应为白细胞减少、恶心呕吐及末梢神经炎．结论草酸铂联合吡柔比星和氟脲嘧啶／甲酰四氢叶酸钙一线治疗晚期胃病的疗效确切，毒副反应能耐受．

The Clinical Study of Oxaliplatin in Combination with Pirarubicin and 5-FU/CF as the First Line Regimen for Advanced/ Metastatic Gastric Cancer

OBJECTIVE: To evaluate the efficacy and safety of oxaliplatin(L-OHP) in combination with pirarubicin(THP) and 5-FU/CF regimen for patients with advanced/ metastatic gastric cancer.METHODS:L-OHP 135 mg/ m~2 iv 3hr day one,THP 35 mg/m~2 iv day one,CF200 mg/d iv 2hr d 1~5,5-FU 400 mg/ m~2 iv d 1~5,repeated every 4 weeks.RESULTS: Fifty six patients have been studied.Four patients achieved CR,26 PR,20 SD and 6 PD.Overall response rate(ORR) were 53.6%.Median time to progress(mTTP) was 4.5 months.Major toxic reactions were neutropenia,nausea,vomiting and peripheral neurotoxicity.CONCLUSION : Oxaliplatin in combination with pirarubicin and 5-FU/CF is a high responsive regimen for advanced gastric cancer with mild toxicity,which can be practiced safely.