运动干预及二甲双胍治疗初2型糖尿病患者疗效的比较

目的:探讨运动干预、二甲双胍及其两者联合治疗对于新诊断2型糖尿病患者治疗效果的差异.方法:60例新诊断2型糖尿病患者,将其随机分为3组,根据所入组别对其进行运动干预、二甲双胍治疗及其联合治疗12周,比较各组治疗前后多项指标的变化情况及疗效的差异.结果:12周后各组患者的BMI,FBG及2hOGTT,HbA1c,INS,TC,TG,LDL-C较治疗前均明显下降(P<0.05),而HDL-C较治疗前明显增加(P<0.05).二甲双胍组与运动干预组比较,治疗后FBG,2hOGTT,HbA1c,INS差异无统计学意义,而运动干预组患者BMI,TC,TG,LDL-C的下降程度及HDL-C的升高程度明显高于二甲双胍组;运动干预联合二甲双胍组治疗后BMI,FBG,2hOGTT,HbA1c,INS,TC,TG、LDL-C下降程度及HDL-C的升高程度均明显高于二甲双胍组及运动干预组(P<0.05).结论:单纯运动干预与二甲双胍治疗对于初发2型糖尿病患者的血糖及胰岛功能的控制疗效相仿,强化运动治疗能明显改善患者的体质及血脂,而二甲双胍联合运动干预对于初诊2型糖尿病患者的血糖、血脂、胰岛功能及体质有明显改善.

Effects of Exercise Theaphy and Metformin in Newlydiagnosed Type 2 Diabetes

Objective:To explore the effects of exercising theaphy and metformin in newly diagnosed type 2diabetes.Methods:there are 60patients who suffer from this kinds of illness,they are divided into 3groups randomly as follows: "exercise" group、 "metformin" group and "exercise+ metformin" group.Every group numbers have been treated for 12weeks,and then find out the difference between the effects.Some related indexes have been measured before and after experiment.Results:After 12weeks,three groups all show a reduction in BMI,FBG,2hOGTT,HbA1c,INS,TC,TG,LDL-C and a increase in HDL-C.There are no diffirence among FBG,2hOGTT,HbA1c,INS in "exercise" group and "metformin" group,but there is a more signifcant reduction of BMI,TC,TG,LDL-C and a increase of HDL-C in "exercise" group than "metformin" group.But "exercise+ metformin" group show a more signifcant effect than "exercise" group and "metformin" group.Conclusion:Both exercise and metformin have a same effect on bood glucose、HbA1c、INS in newly diagnosed type 2diabetes,exercising can signifcantly reduce BMI and blood lipid,But exercise+ metformin"group show a more signifcant effect than "exercise" group and "metformin" group.