Seasonal variation in peripheral blood leukocyte subsets and in serum interleukin-6, and soluble interleukin-2 and-6 receptor concentrations in normal volunteers |
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| Authors: | M Maes W Stevens S Scharpe E Bosmans F De Meyer P D'Hondt D Peeters P Thompson P Cosyns L De Clerck C Bridts H Neels A Wauters W Cooreman |
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| Institution: | (1) Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA;(2) Department of Immunology, University of Antwerp, Wilrijk, (Belgium);(3) Department of Medical Biochemistry, University of Antwerp, Wilrijk, (Belgium);(4) Eurogenetics, Tessenderlo, (Belgium);(5) Department of Geophysics, Royal Meterological Institute, Brussels, (Belgium);(6) Department of Psychiatry, University Hospital of Antwerp, Edegem, (Belgium);(7) Laboratory of Clinical Biology, Middelheim Ziekenhuis, Antwerp, (Belgium);(8) Laboratory of Clinical Biology, St-Augustinus Ziekenhuis, Antwerp, (Belgium);(9) Present address: Department of Psychiatry, University Hospital of Cleveland, School of Medicine, Hanna Pavilion, Room B-68, 2040 Abington Road, 44106 Cleveland, OH, USA |
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| Abstract: | This study has been carried out in order to investigate seasonal variation in peripheral blood immune cells, such as leukocytes, monocytes, neutrophils, lymphocytes, CD3+ T, CD4+ T, CD8+ t, CD25+ T, CD20+ B, and serum interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and sIL-2R levels in normal volunteers. Toward this end, 26 normal volunteers (13 men, 13 women) had monthly blood samplings during one calendar year for peripheral blood count, flow cytometric enumeration of peripheral leukocyte subsets and immunoassays of IL-6, sIL-6R and sIL-2R. It was found that most of the immune variables change rhythmically during the seasons as a group phenomenon. Statistically significant yearly variations with seasonal rhythms, i.e. annual rhythms or harmonics, such as semiannual, tetramensual and trimensual rhythms, were found in the number of leukocytes, neutrophils, monocytes, lymphocytes, CD4+ T, CD8+ T, CD25+ T, CD20+ B cells, in the CD4+/CD8+ ratio, and serum IL-6 and sIL-6R levels. It is concluded that the immune system is characterized by a multifrequency time-structure with significant high-amplitude yearly variations in the number of some peripheral blood leukocyte subsets. |
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| Keywords: | Interleukins leukocytes lymphocytes seasons annual rhythms chronbiology |
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