芳香寡聚磺酰胺大环化合物的合成

以芳香二磺酰氯和芳香二胺为原料, 三乙胺作缚酸剂, 二氯甲烷作溶剂, 用一步成环法合成了一系列新型的、芳环单元不同的芳香磺酰胺四聚体大环化合物3a~6, 并得到了IR, ¹H NMR, MALDI-TOF(matrix assisted laser desorption ionization/time of flight mass spectrometry)等对其结构的确认. 这些大环化合物的对称性和脂溶性较好, 易溶于丙酮中, 重结晶纯化方便可行. 同时发现了制备一系列结构对称的芳香寡聚磺酰胺大环化合物的简单易行的方法, 并对合成方法进行了有价值的探讨.

Synthesis of aromatic oligosulfonamide macrocycles

Aromatic oligosulfonamide macrocyclic compounds were synthesized by one-step macrocyclization using aromatic disulfonyl chlorides and aromatic diamide as the starting materials, triethylamine as the acid binding agent, and dichloromethane as the solvent, resulting in a series of four-residue macrocycles. The purified products were established by IR, ¹H NMR, MALDI-TOF (matrix assisted laser desorption ionization/time of flight mass spectrometry) technique and so on. These macrocycles with symmetry and good liposolubility were soluble easily in acetone, which could be purified conveniently and effectively via recrystallization. In the meanwhile, a simple and effective preparation of a series of symmetrical structure of aromatic oligosulfonamide macrocyclic compounds was presented in this paper, and the synthesis methods were also discussed herein.