人工肝支持系统治疗慢性重型肝炎临床分析

目的：探讨人工肝支持系统（AISS）-血浆置换（PE）在慢性重型肝炎治疗中的疗效及不良反应．方法：将74例慢性重型肝炎患者随机分为治疗组与对照组，两组内科综合治疗相同，治疗组加用PE疗法，观察治疗前后患者临床症状体征、肝功能、凝血酶原活动度（PTA）、血氨（NH3）等指标来判断临床疗效及相关不良反应．结果：治疗组临床好转率68．42％，对照组36．11％，两组比较有显著性差异（P〈0．05）．结论：PE治疗慢性重型肝炎疗效显著，早、中期治疗效果更好，较为安全，值得推广应用．

Clinical Analysis on the Effect of ALSS Treating Chronic Severe Hepatitis

Objective：To study the curative effect and adverse reaction of artificial liver supporting system（ALSS）--plasma exchange（PE） treating chronic severe hepatitis. Methods ：74 cases of this disease were randomly divided into treatment and control groups. Patients in both groups were treated with medical combined treatment, but patients in treatment group were treated with PE simultaneously. The curative effect of two groups was evaluated by clinical symptoms, physical signs,liver function, PTA and blood ammonia of patients before and after treatment. Results： The improvement rate for treatment group was 68.42 %, and that for control group was 36.11%. There was significant difference between two groups （ P 〈 0.05）. Conclusion： PE treating chronic severe hepatitis has excellent results, especially for the patients in early and intermediate phases of this disease ,and it is safe and worth popularizing in clinical activity.