pHi regulatory ion transporters: an update on structure, regulation and cell function |
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Authors: | M. Pucéat |
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Affiliation: | (1) INSERM U390, Laboratoire de Physiopathologie Cardiovasculaire, C.H.U. Arnaud de Villeneuve, Montpellier (France), e-mail: puceat@crbm.cnrs-mop.fr, FR;(2) CRBM, CNRS UPR 1086, Montpellier (France), FR |
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Abstract: | Intracellular pH (pHi) is a major regulator of various and critical cellular functions. A close regulation of pHi is thus mandatory to maintain normal cellular activity. To this end, all cells express ion transporters that carry across their plasma membrane H+ or equivalent H+ into and out of the cell. Besides pHi, these ion transporters are under the regulation of neurohormonal stimuli. This review summarises the molecular identity, regulation and function of the main membrane pH-regulatory ion transporters. Received 30 December 1998; received after revision 4 February 1999; accepted 9 February 1999 |
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Keywords: | . pHi ion transporter Na-H antiport anion exchanger NBC. |
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