New use of BCG for recombinant vaccines |
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| Authors: | C K Stover V F de la Cruz T R Fuerst J E Burlein L A Benson L T Bennett G P Bansal J F Young M H Lee G F Hatfull |
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| Affiliation: | MedImmune Incorporated, Gaithersburg, Maryland 20878. |
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| Abstract: | BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice. |
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