| 新型生物降解交联剂的合成及应用 |
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| 引用本文： | 刘源岗,罗丙红,周长忍.新型生物降解交联剂的合成及应用[J].华侨大学学报(自然科学版),2007,28(4):394-398. |
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| 作者姓名： | 刘源岗 罗丙红 周长忍 |
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| 作者单位： | 华侨大学,材料科学与工程学院,福建,泉州,362021;暨南大学,生物材料研究室,广东,广州,510632 |
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| 基金项目： | 国家重大基础研究(973)项目子课题(G199054306)，福建省青年科技人才创新项目(2006F3079)，华侨大学高层次人才科研启动项目(06BS215) |
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| 摘 要： | 制备出新型两亲性可生物降解聚合物膜.膜由3种成分组成,其一为新型的可生物降解交联剂,用以调节膜的降解速率;其二为亲水单体乙烯基吡咯烷酮,用以提高材料的亲水性,并最终提高材料与细胞的相互作用;其三为羟乙基甲基丙烯酸酯封端聚乳酸,用以调节膜的机械强度,通过傅里叶红外光谱(FTIR)和核磁共振(NMR)分析,结果表明,成功合成可生物降解的交联剂及大分子单体HEMA-PLA,并制备出可应用于组织工程的新型膜材料.
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| 关 键 词： | 交联剂 乙烯基吡咯烷酮 羟乙基甲基丙烯酸酯封端聚乳酸 膜 两亲性 生物降解 |
| 文章编号： | 1000-5013（2007）04-0394-05 |
| 修稿时间： | 2007-02-14 |
Synthesis and Application of Biodegradable Crosslinking Agent |
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| LIU Yuan-gang,LUO Bing-hong,ZHOU Chang-ren.Synthesis and Application of Biodegradable Crosslinking Agent[J].Journal of Huaqiao University(Natural Science),2007,28(4):394-398. |
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| Authors: | LIU Yuan-gang LUO Bing-hong ZHOU Chang-ren |
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| Institution: | 1. College of Materials Science and Engineering, Huaqiao University, Quanzhou 362021, China 2. Laboratory of Biomaterials Research, Jinan University, Guangzhou 510632, China |
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| Abstract: | A novel kind of amphiphilic and biodegradable films were developed. The film mainly is composed of three components: a novel biodegradable crosslinking agent, which is used to adjust the degradable rate of the film;a hydrophilic monomer N-vinyl pyrrolidone (NVP), which is used to improve the material's hydrophilicity, and ultimately improve the interaction between material and cells;a macromonomer 2-hydroxyethyl methacrylate-terminated polylactide acid (HEMA-PLA), which is used to control the film's mechanical strength. These films hopefully will have practical applications in tissue engineering. |
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| Keywords: | crosslinking agent NVP HEMA-PLA film amphiphilic biodegradable |
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